Children of blood and bone epub9/18/2023 ![]() Chronic lead poisoning may be either environmental or occupational. Īcute lead poisoning is mainly related to occupational inhalation and foreign body ingestion. Īnother showed a significant increase in the frequency of chromosomal aberrations in workers exposed to lead compared to the controls. One study showed altered hippocampal volume and brain metabolites in workers occupationally exposed to lead. Lead also depresses haem synthesis and shortens the lifespan of erythrocytes, causing a hypochromic microcytic anaemia. Lead poisoning can cause nervous system toxicity and renal tubular dysfunction leading to irreversible interstitial nephrosis with progressive renal impairment and hypertension. ![]() Lead exposure also affects calcium metabolism. This effects erythrocyte formation by impairing haem synthesis and also depresses the serum level of erythropoietin. Lead inhibits 3 enzymes of haem biosynthesis (δ amino levulinic acid dehydratase (ALAD), coproporphyrin oxidase, and ferrochelatase). ![]() The biological effects of lead are dependent on the level and duration of exposure. ![]()
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